Reported Medical Breakthrough in Preventing Cell Death
AP39, a man-made chemical compound designed at the University of Exeter in Devon, UK, may hold the key to preventing mitochondrial DNA damage in human cells by supplying just enough hydrogen sulfide to diseased cells to keep them viable.
Professor Matt Whiteman, of the University of Exeter Medical School, said: “When cells become stressed by disease, they draw in enzymes to generate minute quantities of hydrogen sulfide. This keeps the mitochondria ticking over and allows cells to live. If this doesn’t happen, the cells die and lose the ability to regulate survival and control inflammation."AP39 could provide breakthroughs in the treatment of conditions such as stroke, heart failure, diabetes, arthritis, dementia and ageing.
"We have exploited this natural process by making a compound, called AP39, which slowly delivers very small amounts of this gas specifically to the mitochondria. Our results indicate that if stressed cells are treated with AP39, mitochondria are protected and cells stay alive.”
Dr. Mark Wood of Biosciences, at the University of Exeter, added “Although hydrogen sulfide is well known as a pungent, foul-smelling gas in rotten eggs and flatulence, it is naturally produced in the body and could in fact be a healthcare hero with significant implications for future therapies for a variety of diseases.”
Posted by Note Taker